Osteoinductive effect of Mineral Trioxide Aggregate versus Portland Cement Type I on mandibular bone lesions
DOI:
https://doi.org/10.59334/ROV.v1i28.156Keywords:
Mineral trioxide aggregate, Portland Cement type I, osteoinduction, osteoblasts, osteocytesAbstract
Introduction: An experimental study was carried out to determine the osteoinductive effect of Mineral Trioxide Aggregate (MTA) versus Portland Cement type I on mandibular bone lesions.
Methodology: Twelve 3-month-old male New Zealand rabbits were divided into 4 equal groups. All rabbits were anesthetized using Pentobarbital. An incision of the mandibular skin was performed to expose the bone on which 3 cavities of 2mm each one were made. In one cavity MTA was placed, in another Portland Cement type I and the third remained empty. The experimental groups were sacrificed at the 1st, 2nd, 3rd and 4th respective weeks and evaluated histologically by counting osteocytes and osteoblasts.
Results: Both MTA and Portland cement have the same osteoinductive capacity in the 1st, 2nd and 3rd week (0.05 <p). Nonetheless, in the 4th week the MTA had greater osteoinductive capacity by stimulating a greater number of osteoblasts than the Portland Cement (p = 0.024).
Conclusions: The MTA and Portland cement type I showed a similar osteoinductive effect during the first 3 weeks of evaluation, however, MTA had the greatest osteoinductive effect during the fourth week of evaluation
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