Surgical management of the patient with hemophilia undergoing oral surgery: A case report
DOI:
https://doi.org/10.59334/ROV.v2i33.405Keywords:
Surgical management, hemophilia, oral surgery, Hematologic Diseases, Blood Coagulation Disorders, Hemorrhagic DisordersAbstract
Introduction: Hemophilia is a congenital deficiency of a coagulation factor, associated to a recessive pattern located in the X chromosome, which induces a lower or even absent functional activity of that factor.
Objective: To provide a narrative review of the literature about haemophiliac patients, as well as a case report of a patient.
Methods: Female patient, 18 years old, attended in the postgraduate of Maxillofacial Surgery of the Andrés Bello University to Santiago, Chile, derived to perform extractions of wisdom teeth due to the end of its orthodontic mechanics. At the anamnesis, the patient reports to suffer from mild hemophilia A, and 6 months ago she had 38% VIII factor. Prior to surgical treatment, a complete blood count with a coagulation test was requested to measure TTPA. In addition, an interconsultation was made with the treating hematologist to perform a hicorrect management to assess of her pathology and recommendations to carry out it with the least amount of intrasurgical and post-surgical risks. Suggested the administration of factor of freeze dried VIII factor before and after surgery. Local hemostasis measures were also applied for better control and proper post-surgical pain
management.
Conclusion: Hemophilia, requires the dentist to perform a thorough management pre, intra and postoperatory, in which complementary tests, communication with the hematologist, atraumatic procedure and a precise management of hemostasis, are key for the treatment’s success.
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References
Ministerio de Salud. “Guía Clínica Hemofilia”. Santiago:Minsal,2013.
Alemandi S., M., S., L., F., & M.X., R. (2014). Manual para el manejo odontológico de Pacientes con Hemofilia y von Willebrand. Manual Odontológico, 1–24.
Anderson, J. A. M., Brewer, A., Creagh, D., Hook, S., Mainwaring, J., McKernan, A., … Yeung, C. A. (2013). Guidance on the dental management of patients with haemophilia and congenital bleeding disorders. British Dental Journal, 215(10), 497–504. https://doi.org/10.1038/sj.bdj.2013.1097
Benson, G., Auerswald, G., Dolan, G., Duffy, A., Hermans, C., Ljung, R., … Salek, S. Z. (2018, November 1). Diagnosis and care of patients with mild haemophilia: Practical recommendations for clinical management. Blood Transfusion. Edizioni SIMTI. https://doi.org/10.2450/2017.0150-17
Bravo, L. M. D. (2012). Consideraciones en el tratamiento odontológico de pacientes pediátricos con Hemofilia. Reporte de un caso clínico. , 86–89. https://doi.org/10.17126/joralres.2012.018
Casas Patarroyo, C. P., Agudelo López, C. D. P., Galvez, K., Lagos Ibarra, J., Martínez Rojas, S., & Ibatá Bernal, L. (2019). [Adequate diagnosis of acquired hemophilia A]. Revista Medica de Chile, 147(3), 334–341. https://doi.org/10.4067/S0034-98872019000300334
Hua, B., Lian, X., Li, K., Lee, A., Poon, M.-C., & Zhao, Y. (2016). Low-dose tertiary prophylactic therapy reduces total number of bleeds and improves the ability to perform activities of daily living in adults with severe haemophilia A: a single-centre experience from Beijing. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis, 27(2), 136–140. https://doi.org/10.1097/MBC.0000000000000389
Knobe, K., & Berntorp, E. (2011). Haemophilia and Joint Disease: Pathophysiology, Evaluation, and Management. Journal of Comorbidity, 1(1), 51–59. https://doi.org/10.15256/joc.2011.1.2
Liras, A., & Romeu, L. (2019). Dental management of patients with haemophilia in the era of recombinant treatments: increased efficacy and decreased clinical risk. BMJ Case Reports, 12(4), e227974. https://doi.org/10.1136/bcr-2018-227974
Mingot-Castellano, M. E., Núñez, R., & Rodríguez-Martorell, F. J. (2017). Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment. Medicina Clínica (English Edition), 148(7), 314–322. https://doi.org/10.1016/j.medcle.2016.11.041
Peters, R., & Harris, T. (2018, July 1). Advances and innovations in haemophilia treatment. Nature Reviews Drug Discovery. Nature Publishing Group. https://doi.org/10.1038/nrd.2018.70
Peyvandi, F., Garagiola, I., & Young, G. (2016, July 9). The past and future of haemophilia: diagnosis, treatments, and its complications. The Lancet. Lancet Publishing Group. https://doi.org/10.1016/S0140-6736(15)01123-X
Sachdeva, A., Gunasekaran, V., Ramya, H. N., Dass, J., Kotwal, J., Seth, T., … Prakash, A. (2018). Consensus Statement of the Indian Academy of Pediatrics in Diagnosis and Management of Hemophilia. Indian Pediatrics, 55(7), 582–590. https://doi.org/10.1007/s13312-018-1302-8
Srivastava, A., Brewer, A. K., Mauser-Bunschoten, E. P., Key, N. S., Kitchen, S., Llinas, A., … Street, A. (2013a). Guidelines for the management of hemophilia. Haemophilia, 19(1). https://doi.org/10.1111/j.1365-2516.2012.02909.x
Srivastava, A., Brewer, A. K., Mauser-Bunschoten, E. P., Key, N. S., Kitchen, S., Llinas, A., … Street, A. (2013b). Guidelines for the management of hemophilia. Haemophilia, 19(1). https://doi.org/10.1111/j.1365-2516.2012.02909.x
Strandberg, K., & Astermark, J. (2018). The role of the laboratory in diagnosis and management of inhibitory antibodies in haemophilia. Haemophilia : The Official Journal of the World Federation of Hemophilia, 24 Suppl 6, 9–14. https://doi.org/10.1111/hae.13474
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