Metabolic relationships of bisphosphonate-induced osteonecrosis of the jaw: review
DOI:
https://doi.org/10.59334/ROV.v2i29.144Keywords:
Bisphosphonates, osteonecrosis of the jaw, antiresorptive, antiangiogenicAbstract
Bifosphonates are antiresorptive drugs of choice in the treatment of a wide range of osteolytic pathologies, such as osteoporosis, Piaget’s disease, hypercalcemia associated with bone metastasis and bone lesions due to multiple myeloma, among others (Adober et ál., 2000). The orally use of these drugs reports adverse effects in the digestive tract: nausea, abdominal pain, heartburn, ulcers and esophageal stenosis (Jódar et ál., 2002). Since 2003, they have also been associated with a bone exposure in the maxilla called bisphosphonate-induced osteonecrosis of jaws; particularly in intravenous application with greater bioavailability (Marx et ál., 2003).
In patients who consume BFs aggressive dental treatments can trigger osteonecrosis of the jaw (Barquero, 2016). The present review focuses on mechanisms of action of BFs that justify their therapeutic action and adverse effects, among them the development of osteonecrosis of jaw; also seeks to It also aims to draw attention to the need to establish dental protocols for patients who are treated with BFs for long periods.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with Odontología Vital agree to the following terms:
- Authors retain the copyright and grant Universidad Latina de Costa Rica the right of first publication, with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license (CC BY-NC-SA 4.0) that allows third parties to copy and redistribute the work in any medium or format, remix, transform, and built upon the work unless it is given appropriate credit, providing a link to the lincese, not using the work for commercial purposes and if the work is remixed, transformed, or built upon, it must be distributed under the same license as the original work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the Odontología Vital's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Métricas alternativas
