Influence of periodontitis on oral squamous cell carcinoma: narrative review
DOI:
https://doi.org/10.59334/ROV.v2i29.151Keywords:
Oral cancer, oral cavity, periodontitisAbstract
Oral squamous cell carcinoma (OSCC) is the most common type of cancer in the mouth, accounting for 95% of all malignancies in the oral cavity. The etiology of OSCC is multifactorial and its pathogenesis has been associated, among others, with the changes that occur in its microenvironment. The inflammation that invades the OSCC microenvironment has been related to the invasion, progression, aggressiveness and prognosis of OSCC. It is for this reason that periodontitis, inflammation of the periodontal tissue, of high prevalence in the adult population, has been related to OSCC. In this regard, clinical studies reported that periodontitis presents a risk for developing OSCC and in vitro studies, reported that periodontitis favors the tumorogenicity and aggressiveness of OSCC. The aim of this review is to describe the effects of periodontitis on oral squamous cell carcinoma.
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Copyright (c) 2018 Jorge Briceño, Daniela Cavagnola, Jorge Candia, Carolina Somarriva, Alejandra Fernández
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