Hereditary Angioedema in Older Adults and Considerations for Dental Treatment
DOI:
https://doi.org/10.59334/ROV.v1i44.682Keywords:
Hereditary angioedema, older adult, elderly, geriatric dentistry, dentistryAbstract
Introduction: Hereditary angioedema (HAE) is a rare inherited disease characterized by recurrent episodes of non-pruritic, non-pitting edema in cutaneous or submucosal tissues. This clinical syndrome is distinguished by a rapid increase in vascular permeability of the affected tissues, not caused by allergic reactions as in common cases of edema. Most research focuses on diagnosing young individuals, but few publications address the topic in the field of geriatrics, and even fewer in dentistry. Objective: To analyze the clinical and dental implications of hereditary angioedema (HAE) in older adult patients in order to establish recommendations for their comprehensive care in geriatric dentistry Methodology: A narrative review of 28 scientific sources published between 2010 and 2025 was conducted, selected from various databases using specific keywords, with the aim of analyzing the pathophysiology, treatment, and dental considerations in older adult patients. Results: Multiple clinical and systemic factors were identified that must be considered in the dental care of older adults with HAE, including the risks associated with invasive procedures, pharmacological interactions, and oral side effects related to treatment. Conclusions: Dental management of patients with HAE is already complex on its own, and when combined with age-related changes, the patient becomes extremely complex. Key aspects must be considered, such as the history of attacks, their triggers and consequences, comorbidities, polypharmacy and its side effects, drug interactions, loss of physical and intellectual function, and the economic investment in the patient's health.
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